Tukysa

Description

Generic Name:

Tucatinib

Description:
Tukysa inhibits HER2, a gene that can play a role in the development of breast cancer and colorectal cancer.

Tukysa is used together with other medicines (trastuzumab and capecitabine) to treat HER2-positive breast cancer. This combination chemotherapy is used when the cancer has spread to other parts of the body or cannot be removed with surgery.

Tukysa is also used together with trastuzumab to treat RAS wild-type HER2-positive colorectal cancer that has spread to other parts of the body or cannot be removed by surgery.

Indication:
Breast cancer and colorectal cancer.

Dosage:
Usual Adult Dose for Breast Cancer:

300 mg orally 2 times a day in combination with trastuzumab and capecitabine until disease progression or unacceptable toxicity

Comments:
-When given in combination with this drug, the recommended dose of capecitabine is 1000 mg/m2 orally 2 times daily taken within 30 minutes after a meal.

Use: in combination with trastuzumab and capecitabine, is indicated for treatment of adult patients with advanced unresectable or metastatic HER2-positive breast cancer, including patients with brain metastases, who have received one or more prior anti-HER2-based regimens in the metastatic setting

Usual Adult Dose for Colorectal Cancer:

300 mg orally 2 times a day combination with trastuzumab until disease progression or unacceptable toxicity

Use: in combination with trastuzumab for the treatment of adult patients with RAS wild-type HER2-positive unresectable or metastatic colorectal cancer that has progressed following treatment with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy.

Precaution & Warnings:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tukysa may affect the way your other medicines work, and other medicines may affect the way Tukysa works.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions and allergies.

Prescription Information:
Proper doctor prescription is needed.
*Note: The prescription should not be older than 6 month.

Contraindication:
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may interact with tucatinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.