Rozlytrek

Description

Generic Name:
Entrectinib

Description:
Rozlytrek is used in adults to treat non-small cell lung cancer that has spread to other parts of the body (metastatic).

Rozlytrek is also used in adults and children at least 12 years old who have solid tumors that have spread or cannot be safely removed with surgery, or when other treatments have failed or are not safe options.

Rozlytrek is used only if your cancer has a specific abnormal gene. Your doctor will test you for this gene.

Indication:
Non-small cell lung cancer

Dosage:
600 mg orally once a day until disease progression or unacceptable toxicity

Use: For adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are ROS1-positive

Usual Adult Dose for Solid Tumors:

600 mg orally once a day until disease progression or unacceptable toxicity

Uses: For adult patients with solid tumors that have a neurotrophic tyrosine receptor kinase (NTRK) gene fusion without a known acquired resistance mutation; are metastatic or where surgical resection is likely to result in severe morbidity; and have progressed following treatment or have no satisfactory alternative therapy.

Usual Pediatric Dose for Solid Tumors:

12 years and older:
-Body surface area (BSA) greater than 1.5 m2: 600 mg orally once a day
-BSA 1.11 to 1.5 m2: 500 mg orally once a day
-BSA 0.91 to 1.1 m2: 400 mg orally once a day

Use: For pediatric patients 12 years and older with solid tumors that have a neurotrophic tyrosine receptor kinase (NTRK) gene fusion without a known acquired resistance mutation; are metastatic or where surgical resection is likely to result in severe morbidity; and have progressed following treatment or have no satisfactory alternative therapy.

Precaution & Warnings:
Rozlytrek may cause new or worsened symptoms of congestive heart failure. Call your doctor at once if you have swelling in your lower legs, rapid weight gain, cough, wheezing, shortness of breath, or trouble breathing while lying down.

Prescription Information:
Proper doctor prescription is needed.
*Note: The prescription should not be older than 6 month.

Contraindication:
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may interact with entrectinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.