Mylotarg

Description

Generic Name:

Gemtuzumab Ozogamicin

Description:
Mylotarg is a monoclonal antibody linked to a chemotherapy drug. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage.

Mylotarg is used to treat a certain type (CD33-positive) of newly-diagnosed acute myeloid leukemia in adults and children at least 1 month old.

Mylotarg is also used to treat CD33-positive acute myeloid leukemia after other treatments did not work or have stopped working in adults and children at least 2 years old

Indication:
Acute myeloid leukemia,CD33-positive acute myeloid leukemia

Dosage:
Newly-diagnosed CD33-positive acute myeloid leukemia (AML):
COMBINATION REGIMEN (therapy consists of 1 induction cycle and 2 consolidation cycles in combination with chemotherapy):
-Induction: 3 mg/m2 (maximum 4.5 mg/dose) IV on Days 1, 4, and 7 in combination with daunorubicin and cytarabine (for patients who require a second induction cycle, gemtuzumab is NOT given during the second induction cycle)
-Consolidation (2 cycles): 3 mg/m2 (maximum 4.5 mg/dose) IV on Day 1 in combination with daunorubicin and cytarabine

Newly-diagnosed CD33-positive acute myeloid leukemia (AML):
SINGLE AGENT REGIMEN (MONOTHERAPY) (therapy consists of 1 induction cycle and up to 8 continuation cycles):
-Induction: 6 mg/m2 IV on Day 1 and 3 mg/m2 IV on Day 8
-Continuation: 2 mg/m2 IV on Day 1 every 4 weeks

Relapsed or Refractory CD33-positive AML:
SINGLE AGENT REGIMEN (MONOTHERAPY):
3 mg/m2 (maximum 4.5 mg/dose) IV on Days 1, 4, and 7
-Treatment in the relapsed or refractory setting consists of a single course of gemtuzumab.

Precaution & Warnings:
Mylotarg can increase your risk of bleeding or liver damage, either of which may be life-threatening.

Call your doctor at once if you have upper stomach pain, yellowing of your skin or eyes, rapid weight gain, swelling in your midsection, sudden numbness or weakness, problems with speech or vision, severe headache, or unusual bleeding (bleeding gums, vaginal bleeding, blood in your urine or stools, coughing up blood).

Prescription Information:
Proper doctor prescription is needed.
*Note: The prescription should not be older than 6 month.

Contraindication:
Mylotarg can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Other drugs interact with gemtuzumab ozogamicin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you s