Calquence

Description

Generic Name:
Acalabrutinib

Description:
Calquence blocks the action of certain enzymes in the body, which can interfere with the growth and spread of cancer cells.

Calquence is used to treat mantle cell lymphoma (a type of non-Hodgkin lymphoma) in adults. This medicine is given after other treatments have failed.

Calquence was approved by the US Food and Drug Administration (FDA) on an “accelerated” basis. In clinical studies, patients responded to this medicine. However, further studies are needed.

Calquence is also used to treat chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) in adults.

Indication:
Mantle cell lymphoma (a type of non-Hodgkin lymphoma) in adults

Dosage:
Usual Adult Dose for Mantle Cell Lymphoma:

100 mg orally approximately every 12 hours
Duration of Therapy: Until disease progression or unacceptable toxicity

Use: Treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. This indication is approved under accelerated approval based on overall response rate. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials.

Usual Adult Dose for Leukemia :

Monotherapy:
100 mg orally every 12 hours
Duration of Therapy: Until disease progression or unacceptable toxicity

In Combination With Obinutuzumab:
100 mg orally every 12 hours
Duration of Therapy: Until disease progression or unacceptable toxicity. Start this drug at Cycle 1 (each cycle is 28 days); start obinutuzumab at Cycle 2 for a total of 6 cycles and refer to the obinutuzumab prescribing information for recommended dosing; administer this drug prior to obinutuzumab when given on the same day

Use: For the treatment of adult patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)

Precaution & Warnings:
Calquence can make it easier for you to bleed. Contact your doctor or seek emergency medical attention if you have any bleeding that will not stop.

Call your doctor at once if you have signs of bleeding inside your body, such as: dizziness, weakness, confusion, headache, speech problems, black or bloody stools, pink or brown urine, or coughing up blood or vomit that looks like coffee grounds.

Prescription Information:
Proper doctor prescription is needed.
*Note: The prescription should not be older than 6 month.

Contraindication:
Many drugs can interact with acalabrutinib. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:

warfarin (Coumadin, Jantoven);

an antibiotic or antifungal medicine;

antiviral medicine to treat hepatitis C or HIV/AIDS;

heart medication; or

a stomach acid reducer – such as omeprazole, lansoprazole Nexium, Prevacid, Prilosec, Protonix, and others.

This list is not complete and many other drugs can interact with acalabrutinib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.